A PGC1α-mediated transcriptional axis suppresses melanoma metastasis
نویسندگان
چکیده
منابع مشابه
GLI2-mediated melanoma invasion and metastasis.
BACKGROUND The transforming growth factor-beta (TGF-beta) pathway, which has both tumor suppressor and pro-oncogenic activities, is often constitutively active in melanoma and is a marker of poor prognosis. Recently, we identified GLI2, a mediator of the hedgehog pathway, as a transcriptional target of TGF-beta signaling. METHODS We used real-time reverse transcription-polymerase chain reacti...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature19347